2022 Mexico GNP | Rank | Player | Country | Team | Goals | Home Goals | Away Goals | Detail |
| 1 | Santiago Ormeno | Peru | Chivas Guadalajara | 4 | 4 | 0 | detail |
| 2 | Paul Brian Rodriguez Bravo | Uruguay | Club America | 2 | 2 | 0 | detail |
| 3 | Alan Torres | Mexico | Chivas Guadalajara | 2 | 2 | 0 | detail |
| 4 | Gustavo Del Prete | Argentina | Pumas U.N.A.M. | 2 | 1 | 1 | detail |
| 5 | Carlos Rodolfo Rotondi | Argentina | CDSyC Cruz Azul | 2 | 1 | 1 | detail |
| 6 | Jonathan Javier Rodriguez Portillo | Uruguay | Club America | 2 | 2 | 0 | detail |
| 7 | Sebastian Saucedo | USA | Toluca | 1 | 1 | 0 | detail |
| 8 | Carlos Gabriel Gonzalez Espindola | Paraguay | Toluca | 1 | 0 | 1 | detail |
| 9 | Juan Gamboa | Mexico | Toluca | 1 | 1 | 0 | detail |
| 10 | Roger Martinez | Colombia | Club America | 1 | 1 | 0 | detail |
| 11 | Salvador Reyes | Mexico | Club America | 1 | 0 | 1 | detail |
| 12 | Javier Ignacio Aquino Carmona | Mexico | Tigres UANL | 1 | 0 | 1 | detail |
| 13 | Jesus Ricardo Angulo Uriarte | Mexico | Tigres UANL | 1 | 0 | 1 | detail |
| 14 | Fierro Sebastian | Tigres UANL | 1 | 1 | 0 | detail | |
| 15 | Brian Avelino Lozano Aparicio | Uruguay | Atlas | 1 | 1 | 0 | detail |
| 16 | Julian Quinones | Mexico | Atlas | 1 | 1 | 0 | detail |
| 17 | Isaac Brizuela Munoz | Mexico | Chivas Guadalajara | 1 | 1 | 0 | detail |
| 18 | Marcelo Javier Correa | Argentina | Santos Laguna | 1 | 0 | 1 | detail |
| 19 | Harold Fabian Preciado Villarreal | Colombia | Santos Laguna | 1 | 0 | 1 | detail |
| 20 | Juan Brunetta | Argentina | Santos Laguna | 1 | 0 | 1 | detail |
| 21 | Diego Javier Medina Vazquez | Mexico | Santos Laguna | 1 | 0 | 1 | detail |
| 22 | Eduard Alexander Bello Gil | Venezuela | Mazatlan FC | 1 | 0 | 1 | detail |
| 23 | Gonzalo Rodrigo Carneiro Mendez | Uruguay | CDSyC Cruz Azul | 1 | 1 | 0 | detail |
| 24 | Alexis Hazael Gutierrez Torres | Mexico | CDSyC Cruz Azul | 1 | 1 | 0 | detail |
| 25 | Edgar Emmanuel Gutierrez | Mexico | CDSyC Cruz Azul | 1 | 0 | 1 | detail |
| 26 | Juan Pablo Segovia Gonzalez | Argentina | Necaxa | 1 | 0 | 1 | detail |
| 27 | Facundo Agustin Batista Ochoa | Uruguay | Necaxa | 1 | 0 | 1 | detail |
| 28 | Juan Ignacio Dinenno | Argentina | Pumas U.N.A.M. | 1 | 1 | 0 | detail |
| 29 | Rodrigo Huescas | Mexico | CDSyC Cruz Azul | 1 | 1 | 0 | detail |
| 30 | Milton Gimenez | Argentina | Necaxa | 1 | 0 | 1 | detail |